医学
免疫抑制
痰
曲菌病
肾移植
烟曲霉
人口
伏立康唑
2019年冠状病毒病(COVID-19)
分离(微生物学)
移植
免疫学
重症监护医学
内科学
疾病
病理
传染病(医学专业)
肺结核
抗真菌
皮肤病科
生物信息学
环境卫生
生物
作者
Hernando Trujillo,Mario Fernández‐Ruiz,Eduardo Gutiérrez,Ángel Sevillano,Fernando Caravaca-Fontán,Enrique Morales,Francisco López‐Medrano,Estela Paz‐Artal,Manuel Praga,Amado Andrés
摘要
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) might increase the risk of invasive pulmonary aspergillosis (IPA). Although several case reports and small series have been reported in the general population, scarce information is available regarding coronavirus disease 2019 (COVID‐19)‐associated IPA in the setting of solid organ transplantation. We describe a case of a kidney transplant recipient with severe COVID‐19 that was subsequently diagnosed with probable IPA on the basis of the repeated isolation of Aspergillus fumigatus in sputum cultures, repeatedly increased serum (1 → 3)‐β‐d‐glucan levels, and enlarging cavitary nodules in the CT scan. The evolution was favorable after initiation of isavuconazole and nebulized liposomal amphotericin B combination therapy and the withdrawal of immunosuppression.
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