干细胞
生物
肠道菌群
平衡
利基
串扰
胃肠道
微生物群
细胞生物学
微生物学
免疫学
生物信息学
生物化学
光学
物理
作者
Peter Yuli Xing,Sven Pettersson,Parag Kundu
出处
期刊:Proteomics
[Wiley]
日期:2020-02-24
卷期号:20 (5-6)
被引量:34
标识
DOI:10.1002/pmic.201800419
摘要
Abstract Microorganisms that colonize the gastrointestinal tract, collectively known as the gut microbiota, are known to produce small molecules and metabolites that significantly contribute to host intestinal development, functions, and homeostasis. Emerging insights from microbiome research reveal that gut microbiota‐derived signals and molecules influence another key player maintaining intestinal homeostasis—the intestinal stem cell niche, which regulates epithelial self‐renewal. In this review, the literature on gut microbiota‐host crosstalk is surveyed, highlighting the effects of gut microbial metabolites on intestinal stem cells. The production of various classes of metabolites, their actions on intestinal stem cells are discussed and, finally, how the production and function of metabolites are modulated by aging and dietary intake is commented upon.
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