A novel BMSC-derived Exosomal circrna promotes angiogenesis by targeting miR-34a-5p to regulate Piezo1

This study provides the first reported circRNA profile of BMSC-derived exosomes in SONFH, identifying novel_circ_0001686 as a key regulator of angiogenesis. By acting through the novel_circ_0001686/miR-34a-5p/Piezo1 axis, it enhances endothelial function and vascular remodeling. These findings imply that novel_circ_0001686 is a promising therapeutic target, underscoring the potential of exosome-based strategies for restoring vascularization and bone homeostasis in SONFH.