Cold‐Induced Pyroelectric Stimulation Enhances Implant Osteointegration via TRPM8 Activation

ABSTRACT Electrical signals serve as important modulators in bone regeneration, yet recreating this self‐sustaining bioelectrical microenvironment at the peri‐implant interface remains challenging. In this study, we engineered pyroelectric nanostructure coatings on titanium (Ti) implants to enhance implant osteointegration through temperature fluctuation‐driven electrical stimulation. The pyroelectric titanium (pyroTi) implants leverage the combined effects of the pyroelectric effect and cold stimulation to amplify calcium ion (Ca 2+ ) influx by activating cold‐sensitive transient receptor potential melastatin 8 (TRPM8) ion channel, therefore driving osteogenic differentiation of bone marrow‐derived mesenchymal stem cells (BMSCs). As a demonstration, pyroTi used as a dental implant in the rabbit maxilla showed enhanced osteointegration under routine cold‐water intake. This study establishes a proof of concept for pyroelectric biomaterials that harness physiological temperature variations to potentiate bone‐implant integration.