Predicting human pharmacokinetic parameters of drugs using a multi-tissue chip platform integrating liver, kidney, and skeletal muscle microphysiological systems

), volume of distribution (VD) and then these parameters were extrapolated to human drug exposures using physiologically based pharmacokinetic (PBPK) modeling. This study demonstrated that the MTC platform could deliver accurate predictions for clinical pharmacokinetics of intravenously administered small molecules without the need for animal studies.