对氧磷酶
医学
芳基二烷基磷酸酶
疾病
脂蛋白
内科学
颈动脉
基因
内分泌学
胆固醇
电源1
氧化应激
生物化学
生物
基因型
作者
Stella Lioudaki,Christos Verikokos,Grigorios Kouraklis,Christos V. Ioannou,Eftychia Chatziioannou,Δέσποινα Περρέα,Chris Klonaris
出处
期刊:Current Vascular Pharmacology
[Bentham Science]
日期:2019-01-09
卷期号:17 (2): 141-146
被引量:10
标识
DOI:10.2174/1570161115666171129212359
摘要
Paraoxonase-1 (PON-1) is a calcium-dependent enzyme that is synthesized in the liver and then secreted in blood where it is bound to high density lipoprotein (HDL). PON-1 is a hydrolase with a wide range of substrates, including lipid peroxides. It is considered responsible for many of the antiatherogenic properties of HDL. PON-1 prevents low density lipoprotein (LDL) oxidation, a process that is considered to contribute to the initiation and development of atherosclerosis. PON-1 activity and levels are influenced by gene polymorphisms; of the 2 common variants, one is in position 192 (Q192R) and one in position 55 (M55L). Also, many drugs affect PON-1 activity. The role of PON-1 in carotid atherosclerosis is inconsistent. Some studies show an association of PON-1 polymorphisms with carotid plaque formation, whereas others do not. The aim of this review is to summarize the characteristics of PON-1, its interactions with drugs and its role in atherosclerosis and especially its relationship with carotid artery disease.
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