Ultrasound-assisted and Efficient Knoevenagel Condensation Reaction Catalyzed by Silica Sodium Carbonate Nanoparticles

An efficient and ultrasound-assisted route to the synthesis of arylidene malononitriles/methylciano-or ethylciano acetates in a onepot reaction catalyzed by silica sodium carbonate nanoparticles (SSC NPs) is described.In this reaction, SSC NPs demonstrated high efficiency as catalyst to obtain target products.By this achievement, a wide range of α,β-unsaturated compounds as Knoevenagel condensation products with good to excellent yields are obtained from reaction between numerous arylaldehydes, and malononitrile, methyl cianoacetate or ethyl cianoacetate.Target products which prepared in high yield and high purity can be candidate as important biologically active molecules.This method is an easy, cheap, rapid and highly efficient for the synthesis of desired products.In addition, capability of catalyst to separate from reaction mixture and reuse in further runs and being compatible with green chemistry are considered as other advantages of this procedure.All products were deduced from their FT-IR and FT-NMR spectroscopic and elemental analysis data.