化学
酰化
利乐
D-氨基葡萄糖
氨基葡萄糖
立体化学
组合化学
有机化学
水解
药物化学
作者
Chi-Hien Dang,Cong-Hao Nguyen,Thanh-Danh Nguyen,Chan Im
出处
期刊:RSC Advances
[The Royal Society of Chemistry]
日期:2014-01-08
卷期号:4 (12): 6239-6245
被引量:10
摘要
Novel 1,3,4,6-tetra-O-acyl-N-acyl-D-glucosamine derivatives were synthesized from glucosamine hydrochloride (GlcN·HCl) by the acylation with pyridine as a catalyst. A derivative of tetra-O-acetyl glucosamine contained ketoprofen, a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects, was first synthesized. In analysis of the NMR spectra, the ratio of α:β-anomer showed that penta-acyl-D-glucosamine derivatives and N-acetylated glucosamines containing O-acyl groups have been only the α-anomer. Meanwhile, both the intermediates and the glucoconjugate compound of ketoprofen have only the β-anomer.
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