Cell migration in the forebrain and the underlying molecular mechanism

During development of the mammalian telencephalon,cells migrate along distinct pathways and reach their final destinations.Pyramidal neurons are generated from cells that migrate radially from the ventricular zone, while interneurons migrate tangentially from ventral ganglionic eminences to the developing cortex.During the process of radial migration,pyramidal neurons adopt soma translocation at first,followed by glial-guided locomotion at the late stage of corticogenesis.Here we summarize the routes of migration in the developing telencephalon,with a particular focus on the radial migration.