Animal Model for Chronic Multi-stress in Rats

Objective:To establish animal model for chronic multi-stress in rats,to provide a platform for study the disease resulted from stress.Method:SD rats were administered with different multi-stress,such as noise,light,electric foot shock and swimming com- bined with immobilization.The behavioral were recorded and analyzed,the heart rate,the blood pressure and the rate of food utilization were examined,and the level of the serum ACTH and hydrocortisone were determined to evaluate the model.Result:There were obvious behavior changes in the rats of model group.Compared with control group,Heart rate,blood pressure and the level of serum ACTH and corticosterone increased significantly,the rate of Food utilization decreased significantly.Conclusion:In this study,the activity of HPA axis enhanced in the rats of model group,the animal model for chronic multi-stress was established successfully.