A polyether polyol was synthesized from sucrose,glycerol and oxypropane.The method of orthogonal test was used and the main influence factors of synthesizing the polyether polyol were studied.The best reaction conditions finally were got: the suitable adding mount proportion of sucrose and glycerol was 1∶1(mole ratio);the best catalyst using amount should be 1% of the whole reactants;the reactor was vacuumized by using N2 to replace three times.Then polymerization reactive temperature was controlled to 95℃;after 1h the best PO feed speed keeping in 5mL/min,the high quality polyether polyol was produced.Based on this result,the synthesis reaction regularity of polyether polyol from sucrose was clearly by more study on the main influence factors.