Pharmacokinetics of sustained release tablets of actarit in Beagle dogs

OBJECTIVE To establish a method for the pharmacokinetics and bioavailability study of atarit in Beagle dogs.METHODS 6 dogs were divided into two groups by double crossing method in two weeks.The concentrations of atarit in plasma were determined by HPLC,and pharmacokinetics parameters were calculated by DAS2.0 program.RESULTS The pharmacokinetics of atarit tablets and atarit sustained release tablets were fitted to one-compartment modle.After dose revised,the results indicated that tmax and t1/2 of atarit sustained release tablets were longer and the Cmax was lower than atarit tablets.The bioavailability of atarit sustained release tablets relative to atarit tablets was(108.9±11.5)%.CONCLUSION Atarit sustained release tablets have marked sustained release characters.