This essay systematically discussed the creation idea and application mode of ‘main disease-main prescription'on the basis of defining the connotation of ‘main disease-main prescription' ‘specific disease-specific prescription' and ‘prescriptions that can cure many diseases'.It also pointed out that ‘main disease-main prescription' is aimed at the main pathogenesis through the whole course of disease, and one prescription is used as the main prescription, modified according to the state of illness, syndrome and constitution of patients.It reflects the view of uniform of disease, constitution and syndrome. It differed from‘specific disease-specific prescription' and prescriptions that can cure many diseases. Its creation idea mainly includes discriminating pathogenesis, differentiating constitutions, transplantation, combination and creation. Its application mode includes main prescription-plus minus, jointed prescriptions-dissemble, constitution regulation prescription and sequential prescription. 2 cases were attached in the back part of the text for further demonstration.