ZEBRAFISH: AN EMERGING MODEL SYSTEM FOR DRUG DISCOVERY

ABSTRACT The zebrafish is no doubt a powerful model organism with a combination of forward and reverse genetics, low cost, amenable high throughput, and rapid in vivo analysis. With these unique features, it can be expected that the zebrafish will become more frequently used for drug discovery. This review outlines the potential of zebrafish to contribute to drug discovery through the identification of novel drug targets, validation of those targets and screening for new therapeutic compounds and assay development. Keywords: Zebrafish, Drug screening, Drug target, Development.