Pharmacokinetics of florfenicol in crucian carp (Carassius auratus cuvieri) after a single intramuscular or oral administration

Zhao, H.‐Y., Zhang, G.‐H., Bai, L., Zhu, S., Shan, Q., Zeng, D.‐P., Sun Y.‐X. Pharmacokinetics of florfenicol in crucian carp (Carassius auratus cuvieri) after a single intramuscular or oral administration.J. vet. Pharmacol. Therap.34, 460–463. The pharmacokinetics of florfenicol (FF) was studied in plasma after a single dose (40 mg/kg) of intramuscular (i.m.) or oral gavage (p.o.) administration to crucian carp (Carassius auratus cuvieri) in freshwater at 25 °C. Ten fish per sampling point were examined after treatment. The data were fitted to two‐compartment open models follow both routes of administration. The estimates of total body clearance (CLb), volume of distribution (Vd/F), and absorption half‐life (T1/2(ka)) were 0.067 L/h/kg and 0.145 L/h/kg, 2.21 L/kg and 1.04 L/kg, 2.75 and 1.54/h following i.m. and p.o. administration, respectively. After i.m. injection, the elimination half‐life (T1/2(β)) was calculated to be 38.2h, the maximum plasma concentration (Cmax) to be 16.82 μg/mL, the time to peak plasma FF concentration (Tmax) to be 1.50 h, and the area under the plasma concentration–time curve (AUC) to be 597.4 μg/mL·h. Following p.o. administration, the corresponding estimates were 2.17 h, 29.32 μg/mL, 1.61 h, and 276.1 μg/mL·h.