生物
干细胞
干细胞疗法
神经干细胞
癌症研究
癌症干细胞
胚胎干细胞
细胞生物学
作者
Rachel Herndon Klein,Paul S. Knoepfler
标识
DOI:10.1016/j.stem.2021.04.013
摘要
Summary In this issue of Cell Stem Cell, Funato et al. (2021) and Bressan et al. (2021) use stem cells as models to define functions of the histone H3.3 G34R mutation in childhood gliomas. Both studies find strong regional specificity to oncohistone activity and implicate specific elements of an aberrantly locked-in neural progenitor transcriptional circuitry.
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