生物
CD8型
表观遗传学
存储单元
细胞毒性T细胞
细胞生物学
记忆T细胞
细胞
免疫记忆
神经科学
计算生物学
遗传学
免疫系统
免疫
基因
体外
物理
晶体管
量子力学
电压
作者
Caitlin C. Zebley,Rama Akondy,Benjamin A. Youngblood,Haydn Kissick
出处
期刊:Cold Spring Harbor Perspectives in Biology
[Cold Spring Harbor Laboratory]
日期:2021-06-14
卷期号:14 (3): a037804-a037804
被引量:2
标识
DOI:10.1101/cshperspect.a037804
摘要
The pool of memory CD8 T cells is comprised of highly specialized subpopulations of cells with both shared and distinct functions. The ongoing study of T-cell memory is focused on how these different subpopulations arise, how the cells are maintained over the life of the host, and how the cells protect a host against reinfection. As a field we have used the convenience of a narrow range of surface markers to define and study these memory T-cell subsets. However, as we learn more about these cells, it is becoming clear that these broad definitions are insufficient to capture the complexity of the CD8 memory T-cell pool, and an updated definition of these cellular states are needed. Here, we discuss data that have recently arisen that highlight the difficulty in using surface markers to functionally characterize CD8 T-cell populations, and the possibility of using the epigenetic state of cells to more clearly define the functional capacity of CD8 memory T-cell subsets.
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