扣带回前部
抗抑郁药
神经科学
氯胺酮
默认模式网络
心理学
神经影像学
无血性
医学
海马体
认知
多巴胺
作者
Laith Alexander,Luke A. Jelen,Mitul A. Mehta,Allan H. Young
标识
DOI:10.1016/j.neubiorev.2021.05.003
摘要
The subdivisions of the anterior cingulate cortex (ACC) – including subgenual, perigenual and dorsal zones – are implicated in the etiology, pathogenesis and treatment of major depression. We review an emerging body of evidence which suggests that changes in ACC activity are critically important in mediating the antidepressant effects of ketamine, the prototypical member of an emerging class of rapidly acting antidepressants. Infusions of ketamine induce acute (over minutes) and post-acute (over hours to days) modulations in subgenual and perigenual activity, and importantly, these changes can correlate with antidepressant efficacy. The subgenual and dorsal zones of the ACC have been specifically implicated in ketamine’s anti-anhedonic effects. We emphasize the synergistic relationship between neuroimaging studies in humans and brain manipulations in animals to understand the causal relationship between changes in brain activity and therapeutic efficacy. We conclude with circuit-based perspectives on ketamine’s action: first, related to ACC function in a central network mediating affective pain, and second, related to its role as the anterior node of the default mode network.
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