生物
遗传学
基因组
水痘带状疱疹病毒
重组
病毒
编码区
DNA测序
计算生物学
基因
作者
Daniel P. Depledge,Judith Breuer
出处
期刊:Current Topics in Microbiology and Immunology
日期:2021-01-01
卷期号:: 1-23
被引量:4
摘要
This chapter first details the structure, organization and coding content of the VZV genome to provide a foundation on which the molecular evolution of the virus can be projected. We subsequently describe the evolution of molecular profiling approaches from restriction fragment length polymorphisms to single nucleotide polymorphism profiling to modern day high-throughput sequencing approaches. We describe how the application of these methodologies led to our current model of VZV phylogeograpy including the number and structure of geographic clades and the role of recombination in reshaping these.
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