进行性核上麻痹
蓝斑
背运动核
基底核
黑质
帕金森病
帕金森病
路易体
病理
医学
神经科学
胶质增生
苍白球
皮质基底变性
中枢神经系统
心理学
疾病
基底神经节
胆碱能神经元
迷走神经
刺激
作者
Kunihiko Araki,Hiroyuki Sumikura,Takashi Matsudaira,Akira Sugiura,Masaki Takao,Shigeo Murayama,Tomokazu Obi
摘要
We describe a woman with a 13‐year history of postural instability, vertical gaze palsy and dopa‐responsive parkinsonism ‐ a clinical profile that corresponds to progressive supranuclear palsy (PSP) and Parkinson's disease (PD). The patient died at the age of 82 years. Neuropathological features included neuronal loss and gliosis in the substantia nigra, locus ceruleus, dorsal motor nucleus of the vagus, thoracic intermediolateral nucleus and nucleus basalis of Meynert, in addition to the typical pathology of PSP. Immunohistochemical studies demonstrated that PSP‐tau pathology was localized in the central nervous system, but Lewy body‐related α‐synucleinopathy was extensive in the central and peripheral nervous systems. Although PSP and PD may represent independent processes, this case could provide insight into a common defect in either protein phosphorylation or the proteinase surveillance system that contributes to human aging.
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