医学
环磷酰胺
抗雌激素
内分泌学
内科学
全身给药
激素
原发性肿瘤
三苯氧胺
化疗
癌症
体内
生物
转移
乳腺癌
生物技术
作者
Bernard Fisher,Elizabeth Saffer,Christine Rudock,Jean Coyle,Nurten Gunduz
出处
期刊:PubMed
日期:1989-04-15
卷期号:49 (8): 2002-4
被引量:49
摘要
This report indicates that not only does the preoperative administration of cyclophosphamide or radiation prevent the kinetic changes observed in a distant tumor focus following tumor removal but that the preoperative administration of the antiestrogen tamoxifen and the luteinizing hormone-releasing hormone analogue Zoladex are equally effective in that regard. It also provides evidence indicating that serum obtained from mice treated with those therapies when transferred to a recipient bearing a tumor of a similar type to that in the donor fails to stimulate DNA synthesis in the tumor of the recipient. In contrast, an increase in labeling index occurs following transfer of serum obtained following tumor removal from untreated mice. Moreover, when tumor-bearing mice were treated by each of the four modalities prior to receiving serum obtained from untreated donors following removal of a tumor, no kinetic changes were observed in the tumor of the serum recipient.
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