化学
细胞毒性
立体化学
细胞毒性T细胞
碳酸钙-2
依托泊苷
结直肠癌
细胞培养
阿扑啡
戒指(化学)
化学合成
IC50型
体外
生物化学
癌症
生物碱
有机化学
化疗
外科
内科学
生物
医学
遗传学
作者
Shashikanth Ponnala,Sandeep Chaudhary,Antonio González‐Sarrías,Navindra P. Seeram,Wayne W. Harding
标识
DOI:10.1016/j.bmcl.2011.06.005
摘要
A series of synthetic aporphine derivatives structurally related to domesticine and nantenine (ring A, N6 and ring C truncated analogs), was evaluated in MTS cytotoxicity assays against the human colon cancer cell lines, HCT-116 and Caco-2. In general, the C1 position of ring A is tolerant of alkoxy substituents as well as a benzoyl ester functionality. Other modifications evaluated resulted in a decrease in cytotoxic activity. The most potent compounds identified had IC50 values in the range 23–38 μM, comparable to the known cytotoxic agent, etoposide.
科研通智能强力驱动
Strongly Powered by AbleSci AI