Chimpanzee Adenovirus Vector Ebola Vaccine

Reactogenicity and immune responses to cAd3-EBO vaccine were dose-dependent. At the 2×10¹¹ particle-unit dose, glycoprotein Zaire-specific antibody responses were in the range reported to be associated with vaccine-induced protective immunity in challenge studies involving nonhuman primates, and responses were sustained to week 48. Phase 2 studies and efficacy trials assessing cAd3-EBO are in progress. (Funded by the Intramural Research Program of the National Institutes of Health; VRC 207 ClinicalTrials.gov number, NCT02231866 .).