Prophylactic action of Liv-52 against lanthanum chloride induced liver injury in male mice

Industrialization and urbanization indicate prosperity and progress. With the advancement of industrialization, the use of chemicals has considerably increased. Many hazardous chemicals like cadmium, mercury, cobalt, beryllium, lanthanum, and cerium are reported to produce a large number of necrotic changes in different organs. In the present study, an attempt has been made to ameliorate the protective actions of an ayurvedic drug Liv-52 against lanthanum chloride induced liver injury. Lanthanum chloride induced numerous histopathological alterations in the liver at the dose of 0.5 m mole/kg body weight. Dose was administered intra peritoneally at once only. A liver cell illustrates hypertrophy, perinuclear vacuolization and disturbed chord arrangements. With the conjoint treatment of Liv-52, liver histoarchitecture was almost maintained after 28 days of exposure.