西塔
川东北74
MHC II级
主要组织相容性复合体
生物
MHC I级
交易激励
干扰素γ
基因
细胞生物学
基因表达
遗传学
免疫系统
作者
Viktor Steimle,Claire Anne Siegrist,Annick Mottet,Barbara Lisowska‐Grospierre,Bernard Mach
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1994-07-01
卷期号:265 (5168): 106-109
被引量:806
标识
DOI:10.1126/science.8016643
摘要
Major histocompatibility complex (MHC) class II genes are expressed constitutively in only a few cell types, but they can be induced in the majority of them, in particular by interferon-gamma (IFN-gamma). The MHC class II transactivator gene CIITA is defective in a form of primary MHC class II deficiency. Here it is shown that CIITA expression is controlled and induced by IFN-gamma. A functional CIITA gene is necessary for class II induction, and transfection of CIITA is sufficient to activate expression of MHC class II genes in class II-negative cells in the absence of IFN-gamma. CIITA is therefore a general regulator of both inducible and constitutive MHC class II expression.
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