体细胞突变
生物
基因
牲畜
抗体
免疫球蛋白轻链
遗传学
免疫球蛋白类转换
生态学
B细胞
作者
Yi Sun,Zhancai Liu,Liming Ren,Zhiguo Wei,Ping Wang,Ning Li,Yaofeng Zhao
标识
DOI:10.1186/2049-1891-3-18
摘要
Abstract This review focuses on the diversity of immunoglobulin (Ig) genes and Ig isotypes that are expressed in domestic animals. Four livestock species—cattle, sheep, pigs, and horses—express a full range of Ig heavy chains (IgHs), including μ, δ, γ, ϵ, and α. Two poultry species (chickens and ducks) express three IgH isotypes, μ, υ, and α, but not δ. The κ and λ light chains are both utilized in the four livestock species, but only the λ chain is expressed in poultry. V(D)J recombination, somatic hypermutation (SHM), and gene conversion (GC) are three distinct mechanisms by which immunoglobulin variable region diversity is generated. Different domestic animals may use distinct means to diversify rearranged variable regions of Ig genes.
科研通智能强力驱动
Strongly Powered by AbleSci AI