外渗
白细胞外渗
单核细胞
免疫系统
人口
免疫学
趋化因子
巡逻
内皮
炎症
CCR2型
趋化因子受体
整合素
生物
医学
细胞生物学
受体
内分泌学
法学
环境卫生
生物化学
政治学
作者
Cédric Auffray,Darin K. Fogg,Meriem Garfa,Gaëlle Elain,Olivier Join‐Lambert,Samer Kayal,Sabine Sarnacki,Ana Cumano,Grégoire Lauvau,Frédéric Geissmann
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2007-08-03
卷期号:317 (5838): 666-670
被引量:1658
标识
DOI:10.1126/science.1142883
摘要
The cellular immune response to tissue damage and infection requires the recruitment of blood leukocytes. This process is mediated through a classical multistep mechanism, which involves transient rolling on the endothelium and recognition of inflammation followed by extravasation. We have shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium. This patrolling behavior depended on the integrin LFA-1 and the chemokine receptor CX 3 CR1 and was required for rapid tissue invasion at the site of an infection by this “resident” monocyte population, which initiated an early immune response and differentiated into macrophages.
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