KAPtain in charge of multiple missions: Emerging roles of KAP1

from conditional knockout mouse models reveal that KAP1-deficiency significantly impairs vital physiological processes, such as immune maturation, stress vulnerability, hepatic metabolism, gamete development and erythropoiesis.In this review, we summarize and evaluate current literatures involving the biochemical and physiological functions of KAP1.In addition, increasing studies on the clinical relevance of KAP1 in cancer will also be discussed.