节点2
树突状细胞
免疫系统
免疫学
T细胞
肿瘤坏死因子α
肠粘膜
生物
先天免疫系统
医学
内科学
作者
Wei Wu,Chong He,Changqin Liu,Anthony Cao,Xiaochang Xue,Heather Evans‐Marin,Mingming Sun,Leilei Fang,Suxia Yao,Irina V. Pinchuk,Don W. Powell,Zhanju Liu,Yingzi Cong
出处
期刊:Gut
[BMJ]
日期:2014-10-03
卷期号:64 (11): 1755-1764
被引量:142
标识
DOI:10.1136/gutjnl-2014-307980
摘要
Our data indicate that miR-10a is decreased in the inflamed mucosa of IBD and downregulates mucosal inflammatory response through inhibition of IL-12/IL-23p40 and NOD2 expression, and blockade of Th1/Th17 cell immune responses. Thus, miR-10a could play a role in the pathogenesis and progression of IBD.
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