化学
环闭合复分解
盐变质反应
串联
复分解
烯丙基重排
秋水仙碱
三环
立体化学
组合化学
有机化学
催化作用
医学
材料科学
内科学
复合材料
聚合
聚合物
作者
François‐Didier Boyer,Issam Hanna
出处
期刊:Organic Letters
[American Chemical Society]
日期:2007-05-18
卷期号:9 (12): 2293-2295
被引量:32
摘要
The synthesis of the tricyclic framework of colchicine has been achieved using a tandem ring-closing metathesis reaction of dienynes as the key step. In this process, both seven-membered rings B and C were formed in one step. Oxidation of tertiary allylic alcohol derived from the tandem metathesis product furnished an intermediate in the total synthesis of colchicine.
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