Gestational organophosphate pesticide exposure and childhood cardiovascular outcomes
有机磷
杀虫剂
医学
环境卫生
毒理
生物
农学
作者
Danielle R. Stevens,Sophia M. Blaauwendraad,Paige A. Bommarito,Michiel A. van den Dries,Leonardo Trasande,Suzanne Spaan,Anjoeka Pronk,Henning Tiemeier,Romy Gaillard,Vincent W. V. Jaddoe,Kelly K. Ferguson
We observed heterogenous associations between gestational organophosphate pesticide exposure and pediatric cardiovascular health: an anti-atherogenic profile was observed for increases in ∑DEAP concentrations, and impairments in multiple aspects of cardiovascular health was observed for increases in ∑DMAP concentrations. PON1-161 and PON1-L55M single nucleotide polymorphisms modified associations for vascular and glycemic outcomes, respectively.