香芹酚
抗菌剂
微生物学
蛋白激酶B
生物化学
蛋白激酶A
信号转导
生物
铜绿假单胞菌
激酶
化学
细菌
遗传学
作者
Muhammad Imran,Mahwish Aslam,Suliman A. Alsagaby,Farhan Saeed,Ishtiaque Ahmad,Muhammad Afzaal,Muhammad Umair Arshad,Mohamed A. Abdelgawad,Ahmed H. El‐Ghorab,Ahmed Khames,Mohammad Ali Shariati,Arslan Ahmad,Muzamal Hussain,Ali Imran,Saiful Islam
摘要
Carvacrol is a major natural constituent and is significantly present as an essential oil in aromatic plants and is well known for its numerous biological activities. Therapeutic properties of carvacrol have been demonstrated as anti-oxidant, anticancer, diabetes prevention, cardioprotective, anti-obesity, hepatoprotective and reproductive role, antiaging, antimicrobial, and immunomodulatory properties. The carvacrol biosynthesis has been mediated through mevalonate pathway. Carvacrol has the anticancer ability against malignant cells via decreasing the expressions of matrix metalloprotease 2 and 9, inducing apoptosis, enhancing the expression of pro-apoptotic proteins, disrupting mitochondrial membrane, suppressing extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signal transduction, and also decreasing the phosphoinositide 3-kinase/protein kinase B. It also decreased the concentrations of alanine aminotransferase, alkaline phosphatase and aspartate aminotransferase, and gamma-glutamyl transpeptidase as well as also restored liver function, insulin level, and plasma glucose level. Carvacrol also has been found to exert antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Coagulase-negative staphylococcus, Salmonella spp., Enterococcus sp. Shigella, and Escherichia coli. The current review article summarizes the health-promoting perspectives of carvacrol through various pathways.
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