化学
催化作用
胺化
表面改性
吡啶
激进的
氰化
光化学
烷基化
选择性
光催化
组合化学
氧化物
反应性(心理学)
有机化学
光催化
物理化学
病理
医学
替代医学
作者
Ban Wang,Cristina Ascenzi Pettenuzzo,Jujhar Singh,Gavin Mccabe,Logan Clark,Ryan M. Young,Jingzhi Pu,Yongming Deng
出处
期刊:ACS Catalysis
日期:2022-08-09
卷期号:12 (16): 10441-10448
被引量:23
标识
DOI:10.1021/acscatal.2c02993
摘要
Readily available and facilely tunable pyridine N-oxides have been developed as effective photoinduced hydrogen-atom-transfer (HAT) catalysts for site-selective C–H functionalizations of a broad range of C–H substrates, including unactivated alkanes. Pyridine N-oxide radicals, catalytically generated from N-oxides by photoredox catalyzed single-electron oxidation, are the key intermediates that enable an effective HAT process for carbon radical generation to achieve alkylation, amination, azidation, allylation, and cyanation. Additionally, the fine-tuning of reactivity and selectivity of pyridine N-oxides through operationally simple structural modification was investigated and showed promising capability for selective functionalization of unactivated C(sp3)–H bonds.
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