阿托品
化学
手性(物理)
对映选择合成
外消旋化
对映体
轴手性
差向异构体
立体化学
计算化学
有机化学
催化作用
物理
手征对称破缺
量子力学
Nambu–Jona Lasinio模型
夸克
作者
Casey B. Roos,Chang-Hwa Chiang,Lauren A. M. Murray,Di Yang,Luke Schulert,Alison R. H. Narayan
出处
期刊:Chemical Reviews
[American Chemical Society]
日期:2023-08-28
卷期号:123 (17): 10641-10727
被引量:10
标识
DOI:10.1021/acs.chemrev.3c00327
摘要
Enantiomers, where chirality arises from restricted rotation around a single bond, are atropisomers. Due to the unique nature of the origins of their chirality, synthetic strategies to access these compounds in an enantioselective manner differ from those used to prepare enantioenriched compounds containing point chirality arising from an unsymmetrically substituted carbon center. In particular stereodynamic transformations, such as dynamic kinetic resolutions, thermodynamic dynamic resolutions, and deracemizations, which rely on the ability to racemize or interconvert enantiomers, are a promising set of transformations to prepare optically pure compounds in the late stage of a synthetic sequence. Translation of these synthetic approaches from compounds with point chirality to atropisomers requires an expanded toolbox for epimerization/racemization and provides an opportunity to develop a new conceptual framework for the enantioselective synthesis of these compounds.
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