巴西褐飞虱
生物
免疫学
肺
CD8型
巨噬细胞
T细胞
免疫系统
医学
生物化学
内科学
体外
作者
Oyebola O. Oyesola,Kerry L. Hilligan,Sivaranjani Namasivayam,Nina Howard,Chad S. Clancy,Mingming Zhao,Sandra D. Oland,Kasalina N Kiwanuka,Nevárez Garza,Bernard A. P. Lafont,Reed F. Johnson,Katrin D. Mayer‐Barber,Alan Sher,P’ng Loke
出处
期刊:Science immunology
[American Association for the Advancement of Science (AAAS)]
日期:2023-08-18
卷期号:8 (86)
被引量:6
标识
DOI:10.1126/sciimmunol.adf8161
摘要
Helminth endemic regions report lower COVID-19 morbidity and mortality. Here, we show that lung remodeling from a prior infection with a lung-migrating helminth, Nippostrongylus brasiliensis , enhances viral clearance and survival of human-ACE2 transgenic mice challenged with SARS-CoV-2 (SCV2). This protection is associated with a lymphocytic infiltrate, including increased accumulation of pulmonary SCV2-specific CD8 + T cells, and anti-CD8 antibody depletion abrogated the N. brasiliensis– mediated reduction in viral loads. Pulmonary macrophages with a type 2 transcriptional and epigenetic signature persist in the lungs of N. brasiliensis –exposed mice after clearance of the parasite and establish a primed environment for increased CD8 + T cell recruitment and activation. Accordingly, depletion of macrophages ablated the augmented viral clearance and accumulation of CD8 + T cells driven by prior N. brasiliensis infection. Together, these findings support the concept that lung-migrating helminths can limit disease severity during SCV2 infection through macrophage-dependent enhancement of antiviral CD8 + T cell responses.
科研通智能强力驱动
Strongly Powered by AbleSci AI