Direct estimation of the noise power spectrum from patient data to generate synthesized CT noise for denoising network training

BACKGROUND: Developing a deep-learning network for denoising low-dose CT (LDCT) images necessitates paired computed tomography (CT) images acquired at different dose levels. However, it is challenging to obtain these images from the same patient. PURPOSE: In this study, we introduce a novel approach to generate CT images at different dose levels. METHODS: Our method involves the direct estimation of the quantum noise power spectrum (NPS) from patient CT images without the need for prior information. By modeling the anatomical NPS using a power-law function and estimating the quantum NPS from the measured NPS after removing the anatomical NPS, we create synthesized quantum noise by applying the estimated quantum NPS as a filter to random noise. By adding synthesized noise to CT images, synthesized CT images can be generated as if these are obtained at a lower dose. This leads to the generation of paired images at different dose levels for training denoising networks. RESULTS: The proposed method accurately estimates the reference quantum NPS. The denoising network trained with paired data generated using synthesized quantum noise achieves denoising performance comparable to networks trained using Mayo Clinic data, as justified by the mean-squared-error (MSE), structural similarity index (SSIM)and peak signal-to-noise ratio (PSNR) scores. CONCLUSIONS: This approach offers a promising solution for LDCT image denoising network development without the need for multiple scans of the same patient at different doses.