Distinct correlation network of clinical characteristics in suicide attempters having adolescent major depressive disorder with non-suicidal self-injury

精神科 重性抑郁障碍 相关性 临床心理学 心理学 自杀预防 毒物控制 伤害预防 精神分裂症(面向对象编程) 人为因素与人体工程学 精神分裂症谱 医学 医疗急救 精神病 认知 几何学 数学
作者
Bo Peng,Ruoxi Wang,Wenlong Zuo,Haitao Liu,Chengwei Deng,Xiaoyuan Jing,Hongtao Hu,Weitan Zhao,Peiwu Qin,Lei Dai,Zuxin Chen,Yingli Zhang,Xin-an Liu
出处
期刊:Translational Psychiatry [Springer Nature]
卷期号:14 (1)
标识
DOI:10.1038/s41398-024-02843-w
摘要

Abstract Suicidal behavior and non-suicidal self-injury (NSSI) are common in adolescent patients with major depressive disorder (MDD). Thus, delineating the unique characteristics of suicide attempters having adolescent MDD with NSSI is important for suicide prediction in the clinical setting. Here, we performed psychological and biochemical assessments of 130 youths having MDD with NSSI. Participants were divided into two groups according to the presence/absence of suicide attempts (SAs). Our results demonstrated that the age of suicide attempters is lower than that of non-attempters in participants having adolescent MDD with NSSI; suicide attempters had higher Barratt Impulsiveness Scale (BIS-11) impulsivity scores and lower serum CRP and cortisol levels than those having MDD with NSSI alone, suggesting levels of cortisol and CRP were inversely correlated with SAs in patients with adolescent MDD with NSSI. Furthermore, multivariate regression analysis revealed that NSSI frequency in the last month and CRP levels were suicidal ideation predictors in adolescent MDD with NSSI, which may indicate that the increased frequency of NSSI behavior is a potential risk factor for suicide. Additionally, we explored the correlation between psychological and blood biochemical indicators to distinguish suicide attempters among participants having adolescent MDD with NSSI and identified a unique correlation network that could serve as a marker for suicide attempters. Our research data further suggested a complex correlation between the psychological and behavioral indicators of impulsivity and anger. Therefore, our study findings may provide clues to identify good clinical warning signs for SA in patients with adolescent MDD with NSSI.
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