生物
人类白细胞抗原
乳腺癌
免疫疗法
细胞毒性T细胞
癌症
癌症研究
HLA-G
转移
癌症免疫疗法
免疫系统
免疫学
肿瘤科
抗原
医学
遗传学
体外
作者
Alexandra Giatromanolaki,Georgios Michos,Erasmia Xanthopoulou,Michael I. Koukourakis
标识
DOI:10.1016/j.cellimm.2024.104816
摘要
Loss of HLA-class-I molecule expression by cancer cells is a frequent event in human tumors that may lead to immune evasion from cytotoxic T-cells. We examined the expression patterns of HLA-class-I molecules in a series of 175 patients with operable breast cancer (BCa). Extensive loss of BCa cell HLA-class-I expression was noted 76.6 % of patients (27.5 % complete loss). A significant association of HLA-preservation with high TIL-density (p = 0.001) was documented. Preservation of HLA was evident only in BCa carcinomas with low HIF1α expression and high TIL-density. Cell line experiments (MCF7 and T47D) showed that induction of HLAs in cancer cells following incubation with lymphocytes or IFNγ, was abrogated under hypoxic conditions. HLA-preservation was linked with better distant metastasis-free survival (p = 0.01), which was confirmed also in multivariate analysis (p = 0.02, HR 3.17). Studying the expression of HLA-class-I molecules in parallel with TIL-density and HIF1α expression may identify subgroups of BCa patients who would benefit from immunotherapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI