核酸
药物输送
生物相容性
纳米技术
材料科学
化学
生物化学
冶金
作者
Feyisayo Eweje,Michelle L. Walsh,Kiran Ahmad,Vanessa Ibrahim,Assma Alrefai,Feyisayo Eweje,Elliot L. Chaikof
出处
期刊:Biomaterials
[Elsevier]
日期:2024-03-01
卷期号:305: 122464-122464
被引量:1
标识
DOI:10.1016/j.biomaterials.2023.122464
摘要
To realize the full potential of emerging nucleic acid therapies, there is a need for effective delivery agents to transport cargo to cells of interest. Protein materials exhibit several unique properties, including biodegradability, biocompatibility, ease of functionalization via recombinant and chemical modifications, among other features, which establish a promising basis for therapeutic nucleic acid delivery systems. In this review, we highlight progress made in the use of non-viral protein-based nanoparticles for nucleic acid delivery in vitro and in vivo, while elaborating on key physicochemical properties that have enabled the use of these materials for nanoparticle formulation and drug delivery. To conclude, we comment on the prospects and unresolved challenges associated with the translation of protein-based nucleic acid delivery systems for therapeutic applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI