Comments on “Analysis of the dissolution behavior and solubility of Rotigotine form II in different mono-solvents”

A polemic is given regarding the calculated enthalpies and entropies of dissolution reported by Yi and coworkers for Rotigotine dissolved in ten organic solvents. The authors’ calculated numerical values, when substituted into the van’t Hoff equation, did not describe the observed mole fraction solubility data. A reanalysis of the reported experimental data found the entropies of dissolution to be positive, as opposed to the very large negative values given in the published paper.