重氮甲烷
硅烷化
迈克尔反应
基质(水族馆)
光化学
化学
催化作用
组合化学
高分子化学
有机化学
海洋学
地质学
作者
Young Woo Kang,Ran Hui Kim,Shafrizal Rasyid Atriardi,Sang Kook Woo
标识
DOI:10.1021/acs.joc.2c02754
摘要
We developed a photocatalyzed Giese reaction of various weakly activated Michael acceptors with a neutral silicon-based radical precursor and applied it at large-scale using a continuous flow reactor. The developed method successfully overcomes the substrate scope limitations of previous studies, shows good functional groups tolerance, and affords good to excellent yields. On the basis of mechanistic studies, we propose a reaction mechanism that involves an in situ generated alkoxymethyl radical via single-electron oxidation of α-trimethylsilyl-substituted ethers.
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