神经酰胺
自噬
神经酰胺合酶
背景(考古学)
细胞生物学
生物
鞘脂
脂质信号
细胞凋亡
癌细胞
癌症
生物化学
酶
遗传学
古生物学
作者
Javad Alizadeh,Simone C. da Silva Rosa,Xiaohui Weng,Joadi Jacobs,Shahrokh Lorzadeh,Amir Ravandi,Rui Vitorino,Stevan Pecic,Aleksandra Živković,Holger Stark,Shahla Shojaei,Saeid Ghavami
标识
DOI:10.1016/j.ejcb.2023.151337
摘要
Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides' fatty acid chain length, subcellular localization, and the presence or absence of their downstream targets. Our current understanding of the role of ceramide synthases and ceramides in regulation of apoptosis and autophagy could be harnessed to pioneer the development of new treatments to activate or inhibit a single type of ceramide synthase, thereby regulating the apoptosis induction or cross talk of apoptosis and autophagy in cancer cells. Moreover, the apoptotic function of ceramide suggests that ceramide analogues can pave the way for the development of novel cancer treatments. Therefore, in the current review paper we discuss the impact of ceramide synthases and ceramides in regulation of apoptosis and autophagy in context of different types of cancers. We also briefly introduce the latest information on ceramide synthase inhibitors, their application in diseases including cancer therapy, and discuss approaches for drug discovery in the field of ceramide synthase inhibitors. We finally discussed strategies for developing strategies to use lipids and ceramides analysis in biological fluids for developing early biomarkers for cancer.
科研通智能强力驱动
Strongly Powered by AbleSci AI