自愈水凝胶
透明质酸
活性氧
药物输送
炎症
氧化应激
生物相容性
化学
体内
明胶
药品
细胞凋亡
细胞生物学
生物物理学
药理学
材料科学
纳米技术
生物化学
免疫学
医学
解剖
生物
生物技术
高分子化学
有机化学
作者
L. Liu,Wantao Wang,Lin Huang,Yiwen Xian,Wenhui Ma,Lifeng Zhao,Yixi Li,Zhaomin Zheng,Hongmei Liu,Decheng Wu
标识
DOI:10.1002/adhm.202400717
摘要
Abstract Chronic local inflammation and excessive cell apoptosis in nucleus pulposus (NP) tissue are the main causes of intervertebral disc degeneration (IDD). Stimuli‐responsive hydrogels have great potential in the treatment of IDD by facilitating localized and controlled drug delivery. Herein, we develop an injectable drug‐loaded dual stimuli‐responsive adhesive hydrogel for microenvironmental regulation of IDD. The gelatin methacryloyl is functionalized with phenylboronic acid groups to enhance drug loading capacity and enable dual stimuli‐responsive behavior, while the incorporation of oxidized hyaluronic acid further improves the adhesive properties. The prepared hydrogel exhibits an enhanced drug loading capacity for diol‐containing drugs, pH‐ and reactive oxygen species (ROS)‐responsive behaviors, excellent radical scavenging efficiency, potent antibacterial activity, and favorable biocompatibility. Furthermore, the hydrogel shows a beneficial protective efficacy on NP cells within an in vitro oxidative stress microenvironment. The in vivo results demonstrate the hydrogel's excellent therapeutic effect on treating IDD by maintaining water retention, restoring disc height, and promoting NP regeneration, indicating that this hydrogel holds great potential as a promising therapeutic approach for regulating the microenvironment and alleviating the progression of IDD. This article is protected by copyright. All rights reserved
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