INSIGHTS INTO THE GENOMIC AETIOLOGY OF OSTEOARTHRITIS: GENOME-WIDE ASSOCIATION STUDY META-ANALYSIS ACROSS 1,962,069 INDIVIDUALS

Purpose (the aim of the study): Osteoarthritis is the most prevalent musculoskeletal disease with over 300 million people affected worldwide. Here, we conduct the largest genome-wide association study (GWAS) meta-analysis for osteoarthritis to date, to gain insight into biological processes underlying osteoarthritis pathophysiology and provide new targets for discovery and translation into therapies.