吗啉
序列(生物学)
寡核苷酸
化学
基因
PMOS逻辑
基因敲除
计算生物学
生物
生物化学
量子力学
物理
电压
晶体管
出处
期刊:Current Opinion in Molecular Therapeutics
日期:2001-06-01
卷期号:3 (3): 235-8
被引量:27
摘要
The phosphorodiamidate morpholino oligomers (PMOs) are a distinct class of oligonucleotide analogs. They bind to RNA and efficiently interfere with gene expression in a sequence-specific manner. Their non-ionic character combined with resistance to degradation in the body offer efficacy with minimal toxicity. Hence, the PMOs are emerging as an excellent approach to therapeutics that can be rationally designed based on target gene sequence data.
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