We compared the preoperative sensitivity of tumor associated glycoprotein (TAG) 12 of 128 primary breast cancer patients with the established tumor marker CA 15-3 and received a similar, even slightly higher sensitivity. In the follow-up the first results showed in some cases different courses of Tag 12 values especially in cases without expression of CA 15-3 whilst in some cases we found an earlier response of TAG 12 to a progression of the disease.