Type I interferon‐induced CD169 + macrophages play a protective role in periodontitis

Periodontitis is one of the major diseases that threaten human health. CD169⁺ macrophages may play a key role in immune homeostasis by producing IL10 and CCL18. The type I interferon-IRF7 axis may induce the differentiation of macrophages into CD169⁺ macrophages, which in turn orchestrates immunomodulation and tissue homeostasis restoration during the recovery phase of periodontitis. Studying the functions and differentiation mechanisms of CD169⁺ macrophages in periodontal tissue may offer new therapeutic targets for periodontitis and provide broader benefits for overall human health.