Pervasive Interactions between Exposures and Polygenic Risk can Inform more Effective Clinical and Behavioral Intervention

R scripts: Pairwise PGSxE using liability threshold disease risk modeling of prevalence vs percentile PGS relationships Amplification using MASH Proportion needed to benefit computation Simulations All figures from the Rshiny app (https://canalization-gibsonlab.shinyapps.io/dualPGSxE/) for (i) prevalence/incidence vs percentile PGS w.r.t pairs of contexts; (ii) chord diagrams showing top context pairs showing PGSxC for each disease; (iii) Proportion needed to benefit (PNB) for each disease and modifiable context pairs.