Longitudinal DCE MRI Vascular Textures: Radiologic and Biologic Insights for pCR Prediction in HER2-Negative Breast Cancer

Dynamic contrast-enhanced (DCE) MRI vascularization-based response tracking (DCE-VASC-TRACK), a predictive model that uses longitudinal DCE MRI data, improved pathologic complete response prediction in human epidermal growth factor receptor 2–negative breast cancer through an integrated framework incorporating biologic pathway analysis and image phenotype characterization to ensure interpretability and robustness.