Indole-3 Acetate Limits Dysbiosis-Driven Diastolic Failure via Hcrt Neurons

This repository contains the data used in the study “Indole-3 Acetate Limits Dysbiosis-DrivenDiastolic Failure via Hcrt Neurons” (DOI: 10.1161/CIRCRESAHA.125.326990). Zebrafish gut full-length 16S rDNA amplicon sequencing:Preprocessed 16S rDNA reads from pooled zebrafish larval gut samples. Data include control and ion-dyshomeostasis larvae (IDL). Preprocessing was carried out by Novogene. Zebrafish gut metabolomics W panel:Raw metabolomics files for all samples (control and IDL). Concentrations are given in ng per 75 zebrafish guts. Sample handling and tryptophan measurements were carried out at the Berlin Institute of Health Metabolomics platform. For full experimental steps and data handling details, please see the online supplementary methods in the original article.